Opportunity Information: Apply for RFA HL 18 021

The Consortium Linking Oncology with Thrombosis (CLOT) (U01) funding opportunity (RFA-HL-18-021) is a National Institutes of Health cooperative agreement designed to build and support a coordinated research program that brings together cancer specialists and experts in coagulation, thrombosis, and vascular biology. The central aim is to speed the movement of discoveries in thrombosis and hemostasis from the research setting into practical, evidence-based approaches that improve care for people with cancer. In plain terms, the program is focused on strengthening team science across oncology and blood/vascular medicine to better understand, prevent, and manage blood clotting and bleeding problems that arise in cancer patients, and to translate those advances into real-world clinical practice.

This opportunity uses the U01 cooperative agreement mechanism, which typically means the funded projects will involve close collaboration with NIH program staff and will operate as part of a larger, coordinated consortium rather than as fully independent investigator-initiated awards. The activity area is health research, and the administering department is the U.S. Department of Health and Human Services through the NIH. The funding announcement was created on July 12, 2017, with an original application closing date of January 8, 2018, indicating it was a time-limited, solicited competition for a defined set of awards.

From a funding perspective, the announcement lists an award ceiling of $500,000 and anticipates making about three awards. That combination signals a relatively selective program intended to support a small number of substantial, collaborative projects that can work in parallel and share knowledge, methods, and outputs in a way that moves the field forward faster than isolated efforts. The program aligns with NIH health-related assistance listings under multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840), reflecting its placement within NIH cardiovascular, hematology, and related translational research portfolios.

Eligibility is broad and includes many types of domestic organizations that can conduct research and manage federal awards. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and certain tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities) other than higher education institutions; for-profit organizations other than small businesses; and small businesses. The announcement also notes an "Others" category with additional eligibility details referenced in the full text, which is common for NIH FOAs that allow certain additional entities or clarify applicant requirements.

Overall, CLOT (U01) is structured to create a formal collaborative environment where oncologists and thrombosis/hemostasis experts jointly develop and implement advances relevant to cancer-associated clotting and bleeding. The underlying intent is not only to generate new knowledge, but to ensure that the resulting insights, tools, and approaches are positioned for adoption in clinical settings, ultimately improving patient outcomes by addressing the complex intersection between malignancy, coagulation, and vascular complications.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortium Linking Oncology with Thrombosis (CLOT) (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
  • This funding opportunity was created on Jul 12, 2017.
  • Applicants must submit their applications by Jan 08, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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