Opportunity Information: Apply for RFA AG 19 009
The NIA AD/ADRD Health Care Systems Research Collaboratory (U54 - Clinical Trial Required) is a National Institute on Aging (NIA), NIH cooperative agreement opportunity (RFA-AG-19-009) designed to strengthen and expand health care systems-based research that improves care for persons with dementia and related dementias (AD/ADRD) and supports their caregivers. The central idea is to build a coordinated, national infrastructure that helps researchers and real-world care organizations work together to test practical, scalable approaches to dementia care using pragmatic clinical trials and demonstration projects embedded in routine health care and long-term services.
A key feature of this funding opportunity is its broad view of what counts as a "health system" or "long-term system." Rather than focusing only on large hospital networks, it explicitly includes a wide range of organizations that deliver dementia-related care across settings. Examples named in the announcement include primary care and specialty outpatient practices, acute inpatient hospitals, skilled nursing facilities and other rehabilitation providers, residential long-term care such as nursing homes and assisted living, and home- and community-based service providers. It also encompasses entities like health maintenance organizations (HMOs), health insurers, managed care plans, memory clinics, federally-designated health centers, outpatient clinics, and other acute or long-term care providers. This wide scope reflects how dementia care often spans multiple settings and transitions over time, and it encourages research that can operate across those boundaries.
The Collaboratory is expected to carry out several major functions. First, it will serve as a national resource that actively promotes the development of pragmatic trials and demonstration projects aimed at improving care processes and health outcomes for people living with dementia and for caregivers. Second, it will directly support pilot pragmatic trials within the Collaboratory structure, meaning it is not only a coordinating center but also an engine for launching and testing initial studies that can later be expanded. Third, it will develop and share technical guidance, policy guidelines, and best practices for conducting AD/ADRD research in partnership with health care systems. In practical terms, that implies producing usable playbooks on topics such as study design in operational settings, data capture using real-world clinical or administrative data, workflow integration, and navigating system-level constraints that affect implementation and sustainability.
Fourth, the Collaboratory will work side-by-side with researchers to provide technical support for scaling up pilot studies, helping promising pilots move toward broader adoption or larger pragmatic trials. Fifth, it will disseminate best practices related to stakeholder engagement and the ethical and operational complexities that arise in dementia research. This includes guidance on conducting ethical research in the special circumstances of dementia care (where issues like decision-making capacity, proxy consent, and caregiver involvement can be central) and on effectively involving both long-term care and acute-care providers who may have different priorities, staffing models, regulatory environments, and data systems.
From an administrative and funding standpoint, this is a discretionary HHS/NIH opportunity using a cooperative agreement mechanism (U54). A cooperative agreement signals substantial NIH involvement during the project, typically through active collaboration, oversight, and scientific or operational partnership rather than a more hands-off grant model. The activity category is health, and the CFDA number listed is 93.866. The opportunity indicates an expected number of awards of one, which suggests NIA planned to fund a single Collaboratory awardee to operate as the national hub. The listing shows an award ceiling of 0, which generally means the specific cap was not stated in the summarized field and would be detailed in the full announcement or negotiated based on scope.
Eligibility is broad and includes many types of applicants that could reasonably host a national collaboratory. Eligible organizations include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other entities as described in the full FOA eligibility text. This breadth supports the goal of building a large, cross-sector infrastructure that can connect academic expertise, health system operations, community-based services, and policy considerations.
In short, this grant opportunity seeks to establish a single, national AD/ADRD Health Care Systems Research Collaboratory that can accelerate practical, health-system-embedded dementia care research by seeding pilot pragmatic trials, producing widely usable technical and policy guidance, supporting scale-up, and spreading best practices for stakeholder engagement and ethically sound research across the full continuum of dementia care settings.Apply for RFA AG 19 009
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "NIA AD/ADRD Health Care Systems Research Collaboratory (U54 - Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Jun 25, 2018.
- Applicants must submit their applications by Sep 06, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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