New Approaches to Identify Neurogenesis and Study its Dynamics in Brain Aging and AD/ADRD (R01 Clinical Trial Not Allowed) | RFA AG 22 006

Opportunity Information: Apply for RFA AG 22 006

The National Institutes of Health (NIH) funding opportunity titled "New Approaches to Identify Neurogenesis and Study its Dynamics in Brain Aging and AD/ADRD (R01 Clinical Trial Not Allowed)" (Funding Opportunity Number RFA-AG-22-006) is a discretionary grant program intended to advance research in the health domain (CFDA 93.866). Its central purpose is to support R01 projects that create genuinely new methods, or substantially improve existing methods, to detect whether neurogenesis is occurring and to measure how neurogenesis changes over time in the context of normal brain aging and in Alzheimer s disease and Alzheimer s disease related dementias (AD/ADRD). A key emphasis is on approaches that can move the field beyond current limitations in identifying new neuron formation and characterizing its timing, rate, location, and biological drivers across aging and disease trajectories.

The announcement is focused on method development and innovative measurement strategies rather than clinical intervention testing. As indicated by "Clinical Trial Not Allowed," applications should not propose clinical trials, meaning the work should not be structured around prospectively assigning human participants to interventions to evaluate health related outcomes. Instead, projects are expected to concentrate on technology, tools, biomarkers, models, analytical frameworks, or other discovery and validation efforts that improve the ability to detect neurogenesis and understand its dynamics in aging and AD/ADRD. In practical terms, this could include developing new labeling or tracing strategies, advanced imaging or molecular techniques, computational or multi-omic approaches, or rigorous enhancements to existing assays that increase sensitivity, specificity, reproducibility, or interpretability when studying neurogenesis in relevant tissues and systems.

The funding mechanism is an NIH R01 research project grant, which generally supports hypothesis driven and tool building research of meaningful scope. The opportunity lists an award ceiling of 500,000, which signals the maximum funding level expected under the announcement (with exact budgets typically depending on NIH policies and the approved scope of work). The original closing date provided is 2021-06-17, and the opportunity record notes a creation date of 2021-01-04. While the listing includes "ExpectedAwards:" without a number, it still conveys that awards were anticipated under the announcement even if the specific count is not provided in the source data.

A wide range of organizations are eligible to apply. Standard eligible applicants include state governments, county governments, city or township governments, special district governments, independent school districts, public and state controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, public housing authorities and Indian housing authorities, and a broad spectrum of nonprofit organizations (including both 501(c)(3) and non 501(c)(3) entities, other than institutions of higher education). The opportunity also allows applications from for profit organizations (other than small businesses) and small businesses, as well as other unspecified eligible entities. In addition, the announcement explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Indian or Native American tribal governments that are not federally recognized, eligible federal agencies, faith based or community based organizations, U.S. territories or possessions, regional organizations, and non U.S. entities (foreign organizations). This broad eligibility signals an intent to encourage diverse institutional participation and to draw on specialized expertise and resources across domestic and international research communities.

In short, this NIH R01 opportunity is aimed at strengthening the scientific toolkit for studying neurogenesis in aging and Alzheimer related conditions, with a strong preference for innovative, enabling approaches that can more reliably establish whether neurogenesis is present and quantify how it changes as the brain ages and as AD/ADRD develops and progresses.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "New Approaches to Identify Neurogenesis and Study its Dynamics in Brain Aging and AD/ADRD (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2021-01-04.
• Applicants must submit their applications by 2021-06-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $500,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AG 22 006

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