Opportunity Information: Apply for HT942525BCRPCREA2
The FY25 DoD Breast Cancer Research Program (BCRP) Clinical Research Extension Award is a discretionary grant opportunity from the Department of the Army (USAMRAA) designed to extend or expand ongoing or previously conducted breast cancer clinical studies. The core purpose is to get more clinically meaningful value from patients participation in clinical research by supporting additional data collection, longer follow-up, and deeper analysis when earlier plans fell short. This mechanism specifically targets situations where important insights may have been left on the table because a trial ended early, participants were not followed long enough to capture key outcomes, or biospecimens and other data were not collected, curated, or analyzed as fully as needed.
The work proposed must connect to at least one of the FY25 BCRP overarching challenges, unless the applicant provides a strong justification for why an exception is appropriate. In practical terms, applicants should be prepared to show how the extension effort will address a defined breast cancer problem and how the added follow-up or additional analyses will change what the field can conclude from an existing clinical study. The emphasis is on clinically relevant impact rather than starting an entirely new clinical trial from scratch; the award is meant to build on prior participant contributions and recover or enhance knowledge that would otherwise be lost.
A defining requirement of this award is meaningful consumer advocacy involvement: the research team must include two or more breast cancer consumer advocates. These advocates are expected to contribute patient-centered perspective to the planning and conduct of the proposed extension work, helping ensure that the questions being answered and the outcomes being prioritized align with patient needs and real-world decision-making. This requirement signals that the program values not only scientific rigor, but also relevance, transparency, and accountability to the breast cancer community.
The funding structure allows either a single Principal Investigator (PI) or a two-PI partnership model. Under the Partnering PI Option, the two leaders are designated as an Initiating PI and a Partnering PI. The submission process is staged: only the Initiating PI submits the pre-application, but both the Initiating and Partnering PIs must submit applications at the full application stage. The program is strict about administrative completeness here: proposals can be withdrawn if both applications are not submitted by the full deadline, or if either the initiating or partnering submission is administratively withdrawn, which effectively makes the partnership incomplete.
Administratively, the opportunity is listed as Funding Opportunity Number HT942525BCRPCREA2 under CFDA 12.420, categorized under Science and Technology and other Research and Development. Eligibility is listed as unrestricted, meaning the program does not limit applicants to a narrow set of institution types in the posted summary. The original closing date is September 10, 2025, and the posting indicates an expectation of one award. While an award ceiling is referenced in the listing, the specific maximum amount is not provided in the text shared, so applicants would need to confirm budget limits and any cost rules in the full announcement package.
Overall, this award is best understood as a mechanism for maximizing the return on existing clinical research investments in breast cancer, especially where additional follow-up time, improved data completeness, or more robust analyses could unlock findings that better inform patient care, survivorship considerations, recurrence risk, long-term safety, or other clinically important endpoints. The program places equal weight on extending the scientific usefulness of prior trials and ensuring the work remains grounded in patient priorities through required consumer advocate participation.Apply for HT942525BCRPCREA2
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer, Clinical Research Extension Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2025-06-16.
- Applicants must submit their applications by 2025-09-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted.
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FY25 DoD BCRP Clinical Research Extension Award (CREA) - FAQs
What is the FY25 DoD Breast Cancer Research Program (BCRP) Clinical Research Extension Award?
It is a discretionary grant opportunity from the Department of the Army (USAMRAA) intended to extend or expand ongoing or previously conducted breast cancer clinical studies. The goal is to increase the clinically meaningful value of prior patient participation by supporting additional data collection, longer follow-up, and deeper analysis.
What is the main purpose of this award?
The core purpose is to maximize what can be learned from existing or completed breast cancer clinical research when earlier study plans did not fully capture key outcomes. This includes situations where a trial ended early, follow-up was too short to observe important endpoints, or biospecimens/data were not collected, curated, or analyzed as fully as needed.
Is this award meant to fund a brand-new clinical trial?
No. The emphasis is on clinically relevant impact by building on prior participant contributions and recovering or enhancing knowledge from an existing clinical study, rather than starting an entirely new clinical trial from scratch.
What kinds of activities does the award support?
Based on the program description provided, supported activities can include additional data collection, extending follow-up duration, and performing deeper or more robust analyses of existing clinical study data. It may also include collecting, curating, and/or analyzing biospecimens and other data that were not fully leveraged under the earlier study plan.
What problem is this award trying to solve?
It targets situations where important clinical insights may have been left unrealized because outcomes were not captured due to early trial closure, insufficient follow-up, incomplete datasets, or underused biospecimens and analyses. The intent is to prevent loss of clinically important knowledge and increase the return on prior clinical research investments.
How does the program define meaningful impact?
The focus is on clinically relevant impact: applicants are expected to show how the added follow-up or additional analyses will change what the field can conclude from an existing clinical study and help address a defined breast cancer problem.
Does the proposed work need to align with the FY25 BCRP overarching challenges?
Yes. The work proposed must connect to at least one of the FY25 BCRP overarching challenges, unless the applicant provides a strong justification for why an exception is appropriate.
What should applicants be prepared to explain about alignment with the BCRP challenges?
Applicants should be prepared to show how the extension effort addresses a defined breast cancer problem and how the additional follow-up and/or analyses will lead to clinically meaningful conclusions from the existing clinical study.
Is consumer advocate involvement required?
Yes. A defining requirement is meaningful consumer advocacy involvement.
How many consumer advocates are required on the research team?
The research team must include two or more breast cancer consumer advocates.
What role are consumer advocates expected to play?
Consumer advocates are expected to contribute a patient-centered perspective to the planning and conduct of the proposed extension work. The intent is to help ensure the questions being addressed and the outcomes prioritized align with patient needs and real-world decision-making.
What does the consumer advocate requirement signal about the program priorities?
It signals that the program values not only scientific rigor, but also relevance, transparency, and accountability to the breast cancer community.
Can the application be submitted with one Principal Investigator (PI), or is a multi-PI team required?
The funding structure allows either a single PI or a two-PI partnership model (the Partnering PI Option).
How does the two-PI (Partnering PI) option work?
Under the Partnering PI Option, the two leaders are designated as an Initiating PI and a Partnering PI. The submission process is staged: only the Initiating PI submits the pre-application, but both the Initiating and Partnering PIs must submit applications at the full application stage.
What happens if both PIs do not submit at the full application stage under the Partnering PI Option?
The program is strict about administrative completeness. Proposals can be withdrawn if both applications are not submitted by the full deadline.
What happens if one PI's application is administratively withdrawn under the Partnering PI Option?
If either the initiating or partnering submission is administratively withdrawn, the partnership is effectively incomplete and the proposal can be withdrawn.
What is the Funding Opportunity Number for this grant?
The Funding Opportunity Number is HT942525BCRPCREA2.
What CFDA number is associated with this opportunity?
The listing references CFDA 12.420.
How is this opportunity categorized?
It is categorized under Science and Technology and other Research and Development.
Who is eligible to apply?
Eligibility is listed as unrestricted in the posted summary, meaning the program does not limit applicants to a narrow set of institution types in the information provided.
What is the application deadline?
The original closing date listed is September 10, 2025.
How many awards does the posting expect to make?
The posting indicates an expectation of one award.
Is there a maximum award amount (award ceiling)?
An award ceiling is referenced in the listing, but the specific maximum amount is not provided in the information shared. Applicants would need to confirm budget limits and any cost rules in the full announcement package.
What types of clinical endpoints or areas might benefit from an extension effort?
The description highlights clinically important endpoints that may require longer follow-up or more complete data, such as patient care implications, survivorship considerations, recurrence risk, long-term safety, and other clinically important outcomes.
Why does the program emphasize extending follow-up and improving data completeness?
Because clinically meaningful insights can be missed if participants are not followed long enough or if data and biospecimens are not sufficiently collected, curated, or analyzed. The award aims to unlock findings that would otherwise remain unavailable despite prior patient participation.
What is the overall intent of the award in relation to prior research investments?
It is intended to maximize the return on existing clinical research investments in breast cancer by extending the scientific usefulness of prior trials and ensuring patient-centered relevance through required consumer advocate participation.
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